New Features in Version 6.0
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Addition of in vitro release data analysis |
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Addition of Freundlich-type binding scheme to skin permeation model |
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Addition of indirect response model to PK-PD model |
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Addition of automatic searching function of steady-state profile to in vitro skin permeation data analysis |
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Improvement of GUI |
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Improvement of deconvolution program for blood concentration data analysis |
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Addition of literature data to parameters list |
Input Parameters
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Patch application time, patch size |
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Device design (diffusion coefficient in matrix, drug loading, etc.) |
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Skin thickness, distance to blood vessels |
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Diffusion and partition coefficients in the skin |
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Systemic pharmacokinetic parameters. |
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Skin metabolism/binding parameters |
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Iontophoretic application parameters |
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Pharmacodynamic parameters, etc. |
Parameters input window.
Output Data
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Cumulative amount of drug permeated across the skin |
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Blood concentration - time profile |
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Distribution of drug concentration in the skin |
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Pharmacologic response - time profile |
Graphical representation window.
| New Features in Version 5.2 |
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Addition of literature database: Diffusion Coefficient in Polymer |
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Addition of literature database: Skin Thickness of Human and Animals |
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Addition of literature database: Diffusion and Partition Coefficients in Skin of human and animals |
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Addition of literature database: Body Pharmacokinetic Parameters following intravenous administration in human |
| New Features in Version 5.1 |
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Vehicle compartment model
Addition of simulation model: Vehicle Compartment + skin diffusion (2-layer or 1-layer) model ... this feature provides simple simulation in the case of "solution" donor phase (e.g. liquid formulation, in vitro permeation system...) |
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Dissolution-controlled model
Modification of simulation model: Dissolution-Controlled Model added to drug-dispersed matrix model ... in this model, dissolution-controlled scheme can be considered as well as diffusion-controlled step for drug release from matrix system |
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PK curve fitting
Modification of [Pharmacokinetics] curve-fitting function ... this feature
provides curve-fitting functions for PK compartment models, which are available
for Continuous Intravenous Infusion and Oral Administration as well as
intravenous bolus injection |
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Deconvolution analysis
Addition of Deconvolution Method ... blood concentration data can be analyzed by deconvolution method together with i.v. bolus data, and fractional absorption can be estimated |
| Improved Features in Version 5.1 |
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Improvement of graph drawing and printing |
| New Features in Version 5.0 |
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Curve fitting function to compartment model
Curve fitting (non-linear regression analysis) function was added in order
to calculate pharmacokinetic parameters. It is applicable to 1-, 2- and
3-comaprtment models from blood concentration data following intravenous
administration. |
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Curve fitting function to Fick's second law
Curve fitting (non-linear regression analysis) function was added in order to calculate diffusion and partition coefficients in the skin. It is applicable to Fick's second law from drug distribution data in the stratum corneum obtained by tape-stripping technique. |
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Search function of in vitro steady-state permeation
Liniear regression program was added in order to determine the steady state
for in vitro skin permeation profiles. This function makes it easy to search
the steady-state profile, to evaluate permeation flux and time lag, and
to calculate diffusion and partition parameters in the skin.
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| Improved Features in Version 5.0 |
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Flexible settings of administration schedule (application period and system size) for multiple dose |
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Calculation of Tmax, Cmax and AUC for multiple administration |
New features in Version 4.1
In version 4.1, diffusional release model of dispersed drug from matrix is added to skin permeation model.
New features in Version 4.0
In version 4.0, pharmacodynamic (PD) analysis is possible and pharmacokinetic (PK) analysis for total body is available
for 1-, 2- and 3-compartmental model. User interface was also upgraded to be easy-to-use. |
| For customers |
Please contact us if you have any questions and comments. |
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